Variable Structure Based Control for the Chemotherapy of Brain Tumor

Brain Tumor is an unwanted mass when cells grow abnormally. It puts pressure on certain areas of the brain which dangerously affects its functioning. For severe tumors like malignant, surgery not a good option because they do have definite boundaries and are closely attached with other healthy tissues brain. So chemotherapy preferable in this case to avoid damaging cells. The primary intention research suggest controller for drug injection so that tumor may reach desired reference value zero. In paper, variable structure based nonlinear control algorithms: sliding mode control, integral double super-twisting controllers been proposed reduce cells, maintain safe number keep immune above ensure suitable amount drug. Lyapunov stability theory has used prove SMC, ISMC, DISMC ST-SMC. MATLAB/Simulink environment analyze performance basis chattering, rate convergence, undershoot/overshoot etc. these results through most advised. Among controllers, due better reduced chattering less used, ST-SMC suggested tumor.